Bioanalytical Chemistry Research Laboratory in Inflammatory Metabolomics

Our research involves applying metabolomics-based technologies to probe diseases of inflammation and dyslipidemia. This work entails the development of both LC/MS and GC/MS methods for the quantification of lipids and other metabolites as well as associated bioinformatics approaches including pathway analysis and relational database construction.

We are also interested in enzymes in the a/b-hydrolase-fold family, with specific emphasis on carboxylesterases. Our work uses synthetic organic chemistry and analytical biochemistry in combination with computational approaches to elucidate enzyme function and inhibitor binding mechanisms. We make extensive use of computer modeling including both classical and 3-D QSAR to address questions of fundamental mechanistic biochemistry.

Craig Wheelock
Division of Physiological Chemistry II
Department of Medical Biochemistry and Biophysics
Karolinska Institutet
Scheeles väg 2
SE-171 77 Stockholm, Sweden